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Charles KHOURI, winner of the 2020 Academic Thesis Award

Charles KHOURI is the winner of the Academic Thesis Award 2020 with 7 other PhDs for his thesis presented in 2019 and entitled "Pharmacology of the microcirculation: Raynaud's phenomenon, trophic diseases and pulmonary arterial hypertension". The academic thesis prizes were awarded to eight Doctors using criteria of excellence specific to each discipline and represented by the 13 doctoral schools on site.
Winner of the 2020 Academic Thesis Award: Charles KHOURI

Charles KHOURI, lauréat du prix de thèse académique 2020Thesis title: Pharmacology of the microcirculation: Raynaud's phenomenon, trophic diseases and pulmonary arterial hypertension

Doctoral school: ED ISCE - Engineering for Health, Cognition and the Environment

Host laboratory: Hypoxia and Cardiovascular and Respiratory Physiopathology (HP2 - Inserm / UGA)

Thesis Supervisor: Jean-luc CRACOWSKI


Key words: Raynaud's phenomenon, drug safety, microcirculation, meta-analysis, pulmonary arterial hypertension, trophic disease

The thesis was carried out in the field of blood microcirculation, focusing more specifically on the impact of drugs in three pathologies, Raynaud's phenomenon, trophic skin disorders and pulmonary arterial hypertension.

Abstract
Microcirculation refers to the subset of the circulatory system where extracellular gas and fluid exchanges take place. It is composed of arterioles, capillaries and venules. Several pathologies are induced by a primary structural and/or functional impairment of this microcirculation: Raynaud's phenomenon (RP), trophic vascular disorders and pulmonary arterial hypertension (PAH). The objectives of this work are to study, understand and identify new iatrogenic etiologies to these microvascular diseases, as well as to evaluate and compare the effectiveness and safety of treatments used in these diseases. We therefore conducted several studies using pharmacovigilance databases, clinical trial data and the literature.This thesis work allowed us to explore the role of drugs in these microvascular pathologies, fields that were poorly studied in the literature yet. This work has allowed us to identify many pharmacological classes whose role was unknown in these diseases. The study of the pharmacological mechanisms underlying these adverse drug reactions also makes it possible to develop new pathophysiological hypotheses underlying these diseases.The treatments used in these different microvascular diseases are currently not specific and important research work still needs to be carried out in order to personalize patient care.

> Discover all the winners of 2020 Thesis Awards


Updated on June 3, 2020

Relocation

The College and the doctoral schools (except Philo) moved on September 1st, 2020 to join the Maison Jean Kuntzmann at 110 rue de la Chimie 38400 Saint-Martin-d'Hères on the University Campus (Tram B and C, stops "Bibliothèques universitaires").
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